- Macrophthalmidae Dana 1851
- Macropodidae Gray 1821
- Macrouridae Bonaparte 1831
- Mactridae Lamarck 1809
- Maeridae Krapp-Schickel 2008
- Magnoliaceae de Jussieu 1789
- Majidae Samouelle 1819
- Malacanthidae Poey 1861
- Malagazziidae Bouillon 1984
- Maldanidae Malmgren 1867
- Malvaceae de Jussieu 1789
- Mantidae Burmeister 1838
- Marteiliidae Sprague 1979
- Matutidae De Haan 1835
- Megachasmidae L.R. Taylor, Compagno & Struhsaker 1983
- Megachilidae Latreille 1802
- Megalopidae Jordan & Gilbert 1883
- Megascolecidae Rosa 1891
- Megathyrididae Dall 1870
- Melicertidae Agassiz 1862
- Melitidae Bousfield 1973
- Menoponidae Mjöberg 1910
- Menyanthaceae Dumortier 1829
- Mermithidae Braun 1883
- Merulinidae Verrill 1865
- Mesodesmatidae Gray 1840
- Mesogammaridae Bousfield 1977
- Mesoveliidae Douglas & Scott 1867
- Metastrongylidae Leiper 1908
- Micrabaciidae Vaughan 1905
- Microdesmidae Regan 1912
- Micropleuridae Baylis & Daubney 1926
- Molgulidae Lacaze-Duthiers 1877
- Miliamminidae Saidova 1981
- Milleporidae Fleming 1828
- Miridae Hahn 1831
- Mithrodiidae Viguier 1878
- Mitridae Swainson 1829
- Moerisiidae Poche 1914
- Molidae Bonaparte 1832
- Molineidae Skrjabin & Schulz 1937
- Monacanthidae Nardo 1842
- Moniliformidae Van Cleave 1924
- Monocentridae Gill 1859
- Montastraeidae Yabe & Sugiyama 1941
- Mopaliidae Dall 1889
- Moraceae Gaudichaud-Beaupré 1835
- Moridae Moreau 1881
- Mugilidae G. Cuvier 1829
- Mullidae Rafinesque 1815
- Munnidae Sars 1897
- Muraenesocidae Kaup 1859
- Muraenidae Rafinesque 1810
- Murchisonellidae Casey 1904
- Muricidae Rafinesque 1815
- Muridae Illiger 1811
- Musaceae de Jussieu 1789
- Mussidae Ortmann 1890
- Mustelidae G. Fischer de Waldheim 1817
- Mycalidae Lundbeck 1905
- Myctophidae T.N. Gill 1893
- Myicolidae Yamaguti 1936
- Myidae Lamarck 1809
- Myliobatidae Bonaparte 1838
- Myocastoridae Ameghino 1902
- Mysidae Haworth 1825
- Mytilicolidae Bocquet & Stock 1957
- Mytilidae Rafinesque 1815
- Myxinidae Rafinesque 1815